Synthesis, characterization and antimicrobial activity of some new azo dyes derived from 4-hydroxy-6-methyl-2H-pyran-2-one and its dihydro derivative

Abstract A series of new azo disperse dyes was synthesized by coupling 4-hydroxy-6-methyl-2H-pyran-2-one (triacetic acid lactone, TAL) or its hydrogenated derivative 4-hydroxy-6-methyl-5,6-dihydro-2H-pyran-2-one (dihydro triacetic DHTAL) with diazonium salts derived from aniline, 4-bromoaniline, 4-nitroaniline, 4-methoxyaniline, 2,4-dimethoxyaniline and 2,5-dimethoxyaniline. Spectroscopic data these dissolved in five organic solvents were measured. The effects solvent polarity, nucleophilic component substituent nature on the visible absorption spectra are also reported. structures all compounds confirmed FT-IR, electronic UV regions, 1H, 13C 2D NMR high resolution mass spectroscopy (HRMS). In addition, vitro antibacterial activity derivatives against Gram positive negative bacteria, both reference clinical strains, evaluated qualitatively quantitatively agar diffusion method.